METABOLISM OF 4-(3-CYCLOHEXYLPROPIONYL)-1-(2-ETHOXYPHE PIPERAZINE (D-16120) BY RAT-LIVER MICROSOMES

被引：0

作者：

CAPUTO, O ^{[1
]}

ROCCO, F ^{[1
]}

GROSA, G ^{[1
]}

机构：

[1] UNIV TURIN,IST CHIM FARMACEUT APPLICATA,I-10125 TURIN,ITALY

来源：

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 1994年 / 19卷 / 04期

关键词：

4-(3-CYCLOHEXYLPROPIONYL)-1-(2-ETHOXYPHENYL); PIPERAZINE; D-16120; DRUG METABOLISM;

D O I：

10.1007/BF03188856

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The metabolic fate of central analgesic 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120), was studied in vitro with phenobarbital 3-methylcholanthrene and clofibrate induced rat liver microsomal fractions. The presence of four metabolites was directly or indirectly established. Biotransformation products were isolated by TIC and HPLC techniques and, when possible, the structures were confirmed through comparison with synthetic samples. The metabolic pathways involved are oxidative dealkylation, aromatic and alicyclic hydroxylation.

引用

页码：303 / 310

页数：8

共 50 条

[21] Involvement of CYP2D1 in the metabolism of carteolol by male rat liver microsomes
Umehara, K
Kudo, S
Odomi, M
XENOBIOTICA, 1997, 27 (11) : 1121 - 1129
[22] REGIOSELECTIVE CONTRIBUTION OF THE CYTOCHROME-P-450 2D SUBFAMILY TO PROPANOLOL METABOLISM IN RAT-LIVER MICROSOMES
MASUBUCHI, Y
KAGIMOTO, N
NARIMATSU, S
FUJITA, S
SUZUKI, T
DRUG METABOLISM AND DISPOSITION, 1993, 21 (06) : 1012 - 1016
[23] DISTRIBUTION, ELIMINATION AND METABOLISM OF 1-(2-PYRIMIDYL)-4-(METHYLENE-C-14-3',4'-DIOXYBENZYL)PIPERAZINE (ET-495)
THOMASSET, M
JOURNAL DE PHARMACOLOGIE, 1971, 2 (02) : 200 - +
[24] KINETICS AND ENZYME INVOLVEMENT IN THE METABOLISM OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE (NNK) IN MICROSOMES OF RAT LUNG AND NASAL-MUCOSA
SMITH, TJ
GUO, Z
HONG, JY
NING, SM
THOMAS, PE
YANG, CS
CARCINOGENESIS, 1992, 13 (08) : 1409 - 1414
[25] METABOLISM OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE IN MOUSE LUNG MICROSOMES AND ITS INHIBITION BY ISOTHIOCYANATES
SMITH, TJ
GUO, Z
THOMAS, PE
CHUNG, FL
MORSE, MA
ELKIND, K
YANG, CS
CANCER RESEARCH, 1990, 50 (21) : 6817 - 6822
[26] METABOLISM OF 3-TERT-BUTYL-4-HYDROXYANISOLE TO 3-TERT-BUTYL-4,5-DIHYDROXYANISOLE BY RAT-LIVER MICROSOMES
ARMSTRONG, KE
WATTENBERG, LW
CANCER RESEARCH, 1985, 45 (04) : 1507 - 1510
[27] LIBERATION OF FREE ALDEHYDE FROM 1-(1-ALKENYL)-SN-GLYCERO-3-PHOSPHOETHANOLAMINE (LYSOPLASMALOGEN) BY RAT-LIVER MICROSOMES
GUNAWAN, J
DEBUCH, H
HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1981, 362 (04): : 445 - 452
[28] ENHANCEMENT OF THE METABOLISM OF CARBON-TETRACHLORIDE BY 2,2'-BIPYRIDINE AND 1,10-PHENANTHROLINE IN RAT-LIVER MICROSOMES
CHEESEMAN, KH
LAI, M
SLATER, TF
IRCS MEDICAL SCIENCE-BIOCHEMISTRY, 1981, 9 (07): : 600 - 600
[29] METABOLISM INVITRO OF 3,4,3',4'-TETRACHLOROBIPHENYL AND 2,5,2',5'-TETRACHLOROBIPHENYL BY RAT-LIVER MICROSOMES AND HIGHLY PURIFIED CYTOCHROME-P-450
ISHIDA, C
KOGA, N
HANIOKA, N
SAEKI, HK
YOSHIMURA, H
JOURNAL OF PHARMACOBIO-DYNAMICS, 1991, 14 (05): : 276 - 284
[30] Analysis of CYP2A contributions to metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human peripheral lung Microsomes
Brown, Pamela J.
Bedard, Leanne L.
Reid, Ken R.
Petsikas, Dimitri
Massey, Thomas E.
DRUG METABOLISM AND DISPOSITION, 2007, 35 (11) : 2086 - 2094

← 1 2 3 4 5 →