CHANGES OF CARBOHYDRATE-DEFICIENT TRANSFERRIN IN CHRONIC-ALCOHOLISM

被引:4
|
作者
KONIG, P [1 ]
NIEDERHOFER, H [1 ]
STEURER, H [1 ]
HALLER, R [1 ]
WOLFLE, R [1 ]
FRITZSCHE, H [1 ]
WEISS, P [1 ]
机构
[1] LANDESKRANKENHAUSES FELDKIRCH, ISOTOPENABT, FELDKIRCH, AUSTRIA
关键词
CARBOHYDRATE-DEFICIENT TRANSFERRIN; LIVER FUNCTION STUDIES; CHRONIC ALCOHOLISM; MONITORING ABSTINENCE;
D O I
10.1159/000119235
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Compared with other well established liver enzyme parameters, carbohydrate-deficient transferrin (CDT) offers a new method for the identification of chronic alcoholism. The dependence of CDT and alcoholism/abstinence was studied in 29 controls and 64 alcoholics (both groups comprising men and women). In contrast to the currently used parameters GOT, GPT, gammaGT, LDH and MCV, CDT measures chronic alcoholism exclusively. CDT is dependent on sex but not age. In chronic alcoholism its rate increases significantly, but drops quickly after a short time of abstinence. CDT variations may be a specific and sensitive indicator of alcoholism or abstinence and possibly the duration.
引用
收藏
页码:192 / 196
页数:5
相关论文
共 50 条
  • [41] Generation of carbohydrate-deficient transferrin by enzymatic deglycosylation of human transferrin
    Duan, CM
    Rosen, S
    Towt, J
    Rouse, S
    Subuhi, H
    Salamone, SJ
    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 1998, 69 (03) : 217 - 224
  • [42] Generation of carbohydrate-deficient transferrin by enzymatic deglycosylation of human transferrin
    Chuanming Duan
    Steven Rosen
    James Towt
    Susan Rouse
    Haleema Subuhi
    Salvatore J. Salamone
    Applied Biochemistry and Biotechnology, 1998, 69 : 217 - 224
  • [43] RELEVANCE OF CARBOHYDRATE-DEFICIENT TRANSFERRIN AS A PREDICTOR OF ALCOHOLISM IN INTENSIVE-CARE PATIENTS FOLLOWING TRAUMA
    SPIES, CD
    EMADI, A
    NEUMANN, T
    HANNEMANN, L
    RIEGER, A
    SCHAFFARTZIK, W
    RAHMANZADEH, R
    BERGER, G
    FUNK, T
    BLUM, S
    MULLER, M
    ROMMELSPACHER, H
    JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1995, 39 (04): : 742 - 748
  • [44] Carbohydrate-deficient transferrin: Marker of actual alcohol consumption or chronic alcohol misuse?
    Mikkelsen, IM
    Kanitz, RD
    Nilssen, O
    Huseby, NE
    ALCOHOL AND ALCOHOLISM, 1998, 33 (06): : 646 - 650
  • [45] SERUM CARBOHYDRATE-DEFICIENT TRANSFERRIN - MECHANISM OF INCREASE AFTER CHRONIC ALCOHOL INTAKE
    XIN, Y
    LASKER, JM
    LIEBER, CS
    HEPATOLOGY, 1995, 22 (05) : 1462 - 1468
  • [46] Effect of Transferrin Glycation on the Use of Carbohydrate-Deficient Transferrin as an Alcohol Biomarker
    Helander, Anders
    Moden, Naama Kenan
    ALCOHOL AND ALCOHOLISM, 2013, 48 (04): : 478 - 482
  • [47] TRANSFERRIN PHENOTYPE AND LEVEL OF CARBOHYDRATE-DEFICIENT TRANSFERRIN IN HEALTHY-INDIVIDUALS
    STIBLER, H
    BORG, S
    BECKMAN, G
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1988, 12 (03) : 450 - 453
  • [48] SERUM LEVELS OF CARBOHYDRATE-DEFICIENT TRANSFERRIN (CDT) IN ALCOHOLICS
    BEAUGE, F
    GIRRE, C
    STIBLER, H
    NIEL, E
    DALLY, S
    ANNALES DE BIOLOGIE CLINIQUE, 1988, 46 (07) : 544 - 544
  • [49] Determination of carbohydrate-deficient transferrin in a Han Chinese population
    Song, Binbin
    Zhu, Jing
    Wu, Jiong
    Zhang, Chunyan
    Wang, Beili
    Pan, Baishen
    Guo, Wei
    BMC BIOCHEMISTRY, 2014, 15
  • [50] Improved HPLC method for carbohydrate-deficient transferrin in serum
    Helander, A
    Husa, A
    Jeppsson, JO
    CLINICAL CHEMISTRY, 2003, 49 (11) : 1881 - 1890