ANTIDEPRESSANT DRUGS INCREASE THE LOCOMOTOR HYPERACTIVITY INDUCED BY MK-801 IN RATS

被引：30
|
作者：
MAJ, J
ROGOZ, Z
SKUZA, G
机构：
[1] Institute of Pharmacology, Polish Academy of Sciences, Kraków
来源：
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1991年 / 85卷 / 03期
关键词：
MK-801; LOCOMOTOR HYPERACTIVITY; ANTIDEPRESSANTS; REPEATED TREATMENT;
D O I：
10.1007/BF01244943
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
MK-801, a non-competitive NMDA receptor antagonist, induced the locomotor hyperactivity in rats. Imipramine (IMI), amitriptyline (AMI), citalopram (CIT) given acutely increased the MK-801-induced locomotor hyperactivity. Mianserin (MIA) showed a similar but weaker effect. Haloperidol completely blocked the hyperactivity induced by the antidepressant drug (AD) + MK-801. Prazosin had an only weak antagonistic effect. Repeated treatment with AD increased the MK-801 locomotor hyperactivity to a greater extent than acute treatment. This effect was completely blocked by haloperidol and only partly by prazosin. The obtained results indicate that the dopamine system may be involved, at least in part, in the potentiating effect of the combined treatment with AD + MK-801.
引用
收藏
页码：169 / 179
页数：11
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