THYROID-FUNCTION TESTING EVALUATED ON 3 IMMUNOASSAY SYSTEMS

被引:6
|
作者
CHRISTENSON, RH
DUH, SH
CLARISSE, DE
ZORN, N
机构
[1] UNIV MARYLAND,SCH MED,DEPT MED & RES TECHNOL,BALTIMORE,MD 21201
[2] UNIV MARYLAND,MED SYST,DIV CLIN CHEM,BALTIMORE,MD 21201
[3] ABBOTT LABS,TECH PROD DEV,ABBOTT PK,IL
关键词
TT4; TSH; T-4;
D O I
10.1002/jcla.1860090306
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Total thyroxine (TT4), tracer uptake, thyroid-stimulating hormone (TSH), and free T-4 (FT4) testing was examined in the ACS 180, Abbott IMx, and Stratus II systems. TSH sensitivity studies demonstrated that the ACS and IMx are second-generation assays; the Stratus showed between first- and second-generation performance. Except for one control below the detection limit, TSH imprecision was 3-10%. TSH accuracy was adequate for all systems. TT4 imprecision was 4-7%, except for the lowest control with the Stratus (18%). TT4 method agreement showed bias of about 20% between the systems. TT4 accuracy was compromised at the low end for the Stratus II, but was satisfactory otherwise. FT4 imprecision was 20% for the Stratus, <5% for the IMx and 6% for the ACS. Uptake assays showed imprecision of 5-10%. The laboratory diagnosis indicated by each system's FT4 and calculated FT4 Index results were compared to determine diagnostic accuracy. In routine specimens, different clinical classifications were observed for 25% of specimens with the ACS, 19% with the Stratus, and 7% with the IMx; in the altered protein group, the Stratus showed 9% discordant results, the ACS showed 3%, and the IMx 0%. Of the three systems examined here, the Abbott IMx system showed the best overall performance. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:178 / 183
页数:6
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