A RISK ASSESSMENT FOR ACRYLONITRILE IN CONSUMER PRODUCTS

被引：3
|
作者：
JOHNSTON, PK [1 ]
ROCK, AR [1 ]
机构：
[1] US CONSUMER PROD SAFETY COMMISS,DIRECTORATE HLTH SCI,BETHESDA,MD 20207
来源：
SCIENCE OF THE TOTAL ENVIRONMENT | 1990年 / 99卷 / 03期
关键词：
D O I：
10.1016/0048-9697(90)90159-R
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
A carcinogenic risk assessment for acrylonitrile in consumer products was prepared as part of the Second Workshop on Pragmatics of Risk Assessment, Bethesda, MD. Data from one inhalation and two oral rat bioassays served as input into several high-to-low-dose mathematical risk extrapolation models. The final unit risk estimates for humans were based on maximum likelihood estimates from the Global83 implementation of the multistage model model after adjustments for surface area differences, continuous versus intermittent exposures, and the proportion of lifetime exposed. The unit risk estimates for lifetime exposure to 1 mg kg-1 day-1 by inhalation and ingestion were 0.0531 and 0.2385, respectively. These risks are eqivalent to risk of 3.3 x 10(-8) for inhalation of 1 ppt in air and 3.4 x 10(-9) for ingestion of 1 ng day-1.
引用
收藏
页码：263 / 279
页数：17
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