SYNTHESIS AND ANTI-HIV ACTIVITY OF 3'-O-FORMYL DERIVATIVES OF THYMIDINE AND 2'-DEOXYURIDINE

被引：3

作者：

KUMAR, R ^{[1
]}

KNAUS, EE ^{[1
]}

WIEBE, LI ^{[1
]}

机构：

[1] UNIV ALBERTA,FAC PHARM & PHARMACEUT SCI,EDMONTON T6G 2N8,ALBERTA,CANADA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1080/07328319208018337

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reaction of the 5'-O-t-butyldimethylsilyl derivatives of thymidine and 2'-deoxyuridine with the Vilsmeier reagent (POCl3/DMF), and removal of the t-butyldimethylsilyl protecting group, afforded 3'-O-formylthymidine (5) and 3'-O-formyl-2'-deoxyuridine (6), respectively. In vitro evaluation, determined as the ability of the test compound to inhibit HIV induced cytopathogenicity in CEM cells, indicated that 5 was moderately active, whereas 6 was inactive.

引用

页码：1219 / 1228

页数：10

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