AGING AND FREE-RADICALS

被引:0
|
作者
GUTTERIDGE, JMC [1 ]
机构
[1] NATL HEART & LUNG INST,LONDON SW3 6NP,ENGLAND
来源
MEDICAL LABORATORY SCIENCES | 1992年 / 49卷 / 04期
关键词
AGE FACTORS; ANTIOXIDANTS; FREE RADICALS;
D O I
暂无
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Mammalian ageing is a universal phenomenon that is both obvious and inevitable, yet poorly understood, and under-researched at the molecular level. Numerous ageing theories have been proposed to explain the progressive and deleterious changes characteristic of ageing. One of the most popular of these is the 'free radical' theory of ageing, which proposes that ageing results from imperfect protection against tissue damage brought about by free radicals. Oxygen free radicals are constantly produced during aerobic metabolism, and certainly provide a universal mechanism for oxidative damage. However, a major obstacle to acceptance of the theory has been the poor record of antioxidants in prolonging the lifespan of small animals. Many other variables, such as genetic factors, temperature, activity and nutrition can affect lifespan, making it a highly complex multi-factorial process.
引用
收藏
页码:313 / 318
页数:6
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