EXPERIMENTS DIRECTED TOWARDS THE SYNTHESIS OF ANTHRACYCLINONES .23. A SYNTHESIS OF FRIDAMYCIN-E

被引：8
|
作者：
PAUSLER, MG [1 ]
RUTLEDGE, PS [1 ]
机构：
[1] UNIV AUCKLAND,DEPT CHEM,AUCKLAND,NEW ZEALAND
来源：
AUSTRALIAN JOURNAL OF CHEMISTRY | 1994年 / 47卷 / 12期
关键词：
Anthracyclinones - Enolates - Fridamycin - Menthyl acetate - Solvomercuration;
D O I：
10.1071/CH9942135
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Fridamycin E (1) has been synthesized in six steps from the anthrarufin mono(chloroallyl) ether (10). The synthesis was based on a titanium-mediated aldol-like addition of a (-)-menthyl acetate enolate to the ketone (9). Similar additions to the aldehydes (23) and (25) are reported.
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页码：2135 / 2147
页数：13
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