CYANOGEN IODIDE - A NEW REAGENT FOR DISULFIDE BOND FORMATION IN PEPTIDES

被引：11

作者：

BISHOP, P ^{[1
]}

CHMIELEWSKI, J ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT CHEM,W LAFAYETTE,IN 47907

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 42期

关键词：

D O I：

10.1016/S0040-4039(00)60948-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three cyclic disulfides were formed from linear analogs of calcitonin, epidermal growth factor (EGF), and a fragment of the DNA-binding Cro protein using a new reagent: cyanogen iodide (ICN). Each peptide contained two S-protected cysteine derivatives [Cys(Acm)] which were deprotected with concurrent disulfide bond formation. A comparison with I2, a common reagent for this reaction, is included.

引用

页码：6263 / 6266

页数：4

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