P-GLYCOPROTEIN AND DRUG-RESISTANCE IN ACUTE LEUKEMIAS AND IN THE BLASTIC CRISIS OF CHRONIC MYELOID-LEUKEMIA

被引：0
|
作者：
CARULLI, G
PETRINI, M
MARINI, A
VAGLINI, F
CARACCIOLO, F
GRASSI, B
机构：
[1] UNIV PISA,MED CLIN 1,UNITA EMATOL,I-56100 PISA,ITALY
[2] UNIV PISA,IST FARMACOL,I-56100 PISA,ITALY
来源：
HAEMATOLOGICA | 1990年 / 75卷 / 06期
关键词：
CHEMORESISTANCE; LEUKEMIA; MULTIDRUG RESISTANCE; P-GLYCOPROTEIN; P-170;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of this work is to evaluate the relationship between P-glycoprotein expression in circulating blasts and clinical response in patients suffering from acute lymphoblastic leukemia, acute non-lymphoblastic leukemia, and chronic myeloid leukemia in either lymphoid or myeloid blastic crisis. The results obtained show that: a) patients whose blasts express P-glycoprotein are resistant towards protocols including Doxorubicin, Daunorubicin, Etoposide, Mithramycin, Vincristine; b) P-glycoprotein can be expressed constitutively in some cases; c) P-glycoprotein does not appear to be the only mechanism responsible for resistance towards anthracyclines and Etoposide.
引用
收藏
页码：516 / 521
页数：6
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