Wide band-gap semiconductor detectors have good application prospects in the compact systems intended for detecting low-level radiation and identifying radionuclides. In the present work, the algorithm of identification of radionuclides and determination of their quantitative characteristics was researched. The responses of CdZnTe- and TlBr-detectors to radiation from Cs-137, Sr-90, K-40, I-131 and Co-60 were simulated by Monte-Carlo method via GEANT4 v. 4.9.6 package for realization of this algorithm. It allowed us to create a databases of spectral signatures for the investigated detectors and to use them as input data for the regression model.