PHASE-II STUDY OF ETOPOSIDE AND ALPHA-INTERFERON IN PATIENTS WITH ADVANCED MEASURABLE COLORECTAL-CARCINOMA

被引：1
|
作者：
AJANI, JA
ABBRUZZESE, JL
MARKOWITZ, AB
PATT, YZ
DAUGHERTY, K
机构：
[1] Section of Gastrointestinal Oncology, Department of Medical Oncology, Division of Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas
来源：
INVESTIGATIONAL NEW DRUGS | 1993年 / 11卷 / 01期
关键词：
ETOPOSIDE; ALPHA-INTERFERON; COLORECTAL CARCINOMA;
D O I：
10.1007/BF00873914
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Based on encouraging in vitro and in vivo data, 14 consecutive patients with measurable metastatic previously untreated colorectal carcinoma were treated with a combination of intravenous etoposide and subcutaneous alpha-interferon. Etoposide was given at 60 mg/m2 intravenously on days 1-5 and alpha-interferon at 5 million units/m2 subcutaneously on days 1-5; courses were repeated every 21 days. All 14 patients were evaluable for response and toxicity. None of the patients achieved a complete or partial remission. Toxicity of this combination was moderate. Our data suggest that this combination is ineffective against colorectal carcinoma.
引用
收藏
页码：67 / 69
页数：3
相关论文
共 50 条
  • [41] TREATMENT OF METASTATIC COLORECTAL-CARCINOMA WITH LYMPHOBLASTOID INTERFERON AND 5-FLUOROURACIL - DATA OF A PHASE-II STUDY
    BARZACCHI, MC
    NOBILE, MT
    SANGUINETI, O
    SERTOLI, MR
    CHIARA, S
    REPETTO, L
    FORNO, G
    LAVARELLO, A
    ROSSO, R
    ANTICANCER RESEARCH, 1994, 14 (5B) : 2147 - 2149
  • [42] PHASE-II STUDY OF MOF-STREP (METHYL-CCNU, VINCRISTINE, 5-FLUOROURACIL, STREPTOZOTOCIN) IN ADVANCED MEASURABLE COLORECTAL-CARCINOMA
    SMITH, FP
    SMITH, FP
    ELLENBERG, SS
    MAYER, RJ
    LESSNER, HE
    HORTON, J
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1982, 23 (MAR): : 149 - 149
  • [43] PHASE-II STUDY OF ALPHA-INTERFERON ON RENAL-CELL CARCINOMA - SUMMARY OF 3 COLLABORATIVE TRIALS
    UMEDA, T
    NIIJIMA, T
    CANCER, 1986, 58 (06) : 1231 - 1235
  • [44] PHASE-II TRIAL OF FLUOROURACIL AND RECOMBINANT INTERFERON ALFA-2A IN PATIENTS WITH ADVANCED COLORECTAL-CARCINOMA - AN EASTERN-COOPERATIVE-ONCOLOGY-GROUP STUDY
    WADLER, S
    LEMBERSKY, B
    ATKINS, M
    KIRKWOOD, J
    PETRELLI, N
    JOURNAL OF CLINICAL ONCOLOGY, 1991, 9 (10) : 1806 - 1810
  • [45] A PHASE-II STUDY OF RECOMBINANT ALPHA-INTERFERON IN PATIENTS WITH RECURRENT OR METASTATIC BREAST-CANCER
    MUSS, HB
    KEMPF, RA
    MARTINO, S
    RUDNICK, SA
    GREINER, J
    COOPER, MR
    DECKER, D
    GRUNBERG, SM
    JACKSON, DV
    RICHARDS, F
    SAMAL, B
    SINGHAKOWINTA, A
    SPURR, CL
    STUART, JJ
    WHITE, DR
    CAPONERA, M
    MITCHELL, MS
    JOURNAL OF CLINICAL ONCOLOGY, 1984, 2 (09) : 1012 - 1016
  • [46] PHASE-II STUDY OF ESORUBICIN IN PATIENTS WITH ADVANCED COLORECTAL-CARCINOMA AND NO PRIOR CHEMOTHERAPY - AN ILLINOIS-CANCER-COUNCIL TRIAL
    LOCKER, GY
    HOELTGEN, T
    KILTON, L
    KRAUSS, S
    MCNAMARA, M
    BLOUGH, R
    JOHNSON, C
    CANCER TREATMENT REPORTS, 1987, 71 (7-8): : 765 - 766
  • [47] A PHASE-II STUDY OF INTRAVENOUS 6-THIOGUANINE (NSC-752) IN ADVANCED COLORECTAL-CARCINOMA
    RUBIN, J
    SCHUTT, AJ
    PITOT, HC
    AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 1992, 15 (03): : 236 - 238
  • [48] PHASE-II TRIAL OF 5-FU PLUS MELPHALAN IN ADVANCED COLORECTAL-CARCINOMA
    GOUGH, IR
    FURNIVAL, CM
    THYNNE, GSJ
    BURNETT, W
    CANCER TREATMENT REPORTS, 1981, 65 (7-8): : 735 - 736
  • [49] CISPLATIN AND 5-FLUOROURACIL COMBINATION CHEMOTHERAPY IN ADVANCED AND OR METASTATIC COLORECTAL-CARCINOMA - A PHASE-II STUDY
    GALLIGIONI, E
    CANOBBIO, L
    FIGOLI, F
    FASSIO, T
    FRUSTACI, S
    CRIVELLARI, D
    VACCHER, E
    RE, GL
    GASPARINI, G
    VERONESI, A
    MONFARDINI, S
    EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1987, 23 (06): : 657 - 661
  • [50] PHASE-II TRIAL OF 4-DEMETHOXY DAUNORUBICIN (DMDR) IN ADVANCED COLORECTAL-CARCINOMA
    HARPER, H
    KEMENY, N
    CHENG, E
    SORDILLO, P
    AHMED, T
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1983, 24 (MAR): : 148 - 148
12345