PHASE-II STUDY OF ETOPOSIDE AND ALPHA-INTERFERON IN PATIENTS WITH ADVANCED MEASURABLE COLORECTAL-CARCINOMA

被引：1
|
作者：
AJANI, JA
ABBRUZZESE, JL
MARKOWITZ, AB
PATT, YZ
DAUGHERTY, K
机构：
[1] Section of Gastrointestinal Oncology, Department of Medical Oncology, Division of Medicine, University of Texas M.D. Anderson Cancer Center, Houston, Texas
来源：
INVESTIGATIONAL NEW DRUGS | 1993年 / 11卷 / 01期
关键词：
ETOPOSIDE; ALPHA-INTERFERON; COLORECTAL CARCINOMA;
D O I：
10.1007/BF00873914
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Based on encouraging in vitro and in vivo data, 14 consecutive patients with measurable metastatic previously untreated colorectal carcinoma were treated with a combination of intravenous etoposide and subcutaneous alpha-interferon. Etoposide was given at 60 mg/m2 intravenously on days 1-5 and alpha-interferon at 5 million units/m2 subcutaneously on days 1-5; courses were repeated every 21 days. All 14 patients were evaluable for response and toxicity. None of the patients achieved a complete or partial remission. Toxicity of this combination was moderate. Our data suggest that this combination is ineffective against colorectal carcinoma.
引用
收藏
页码：67 / 69
页数：3
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