SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF NOVEL 2-(BENZO[D][1,3]DIOXOL-5-YL)-6,7-DIMETHOXYLQUINAZOLIN-4(3H)-ONES

被引：0

作者：

Kancharla, Suman ^{[1
]}

BharathYarlagadda ^{[1
]}

Murthy, Ch S. S. S. ^{[1
]}

Devunuri, Nagaraju ^{[1
]}

机构：

[1] Vignans Univ, Dept Sci & Humanities, Vadlamudi 522213, AP, India

来源：

HETEROCYCLIC LETTERS | 2015年 / 5卷 / 04期

关键词：

Antimicrobial activity; 4; 5-Dimethoxy-2-nitrobenzamide; SnCl2 center dot 2H(2)O; thionyl chloride;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In view of generatingnew compounds for future drug development, we have synthesized some 2-(benzo[d][1,3]dioxol-5-yl)-6,7-dimethoxylquinazolin-4(3H)-one derivatives of 4,5-dimethoxy-2-nitrobenzamide (5), synthesized by the ortho-nitro acid 4 was converted to its acid chloride by using thionyl chloride, followed by treatment with ammonia (aq.) gave the substituted ortho-nitro benzanilide (5). 4,5-Dimethoxy-2-nitrobenzamide (5) react withbenzo(d)[1,3] dioxole-5-carbaldehyde (6a) in presence of SnCl2 center dot 2H(2)O in MeOH was heated to gave 2-(benzo[d][1,3]dioxol-5-yl)-6,7-dimethoxylquinazolin-4(3H)-ones (7a-k). All the synthesized compounds were fully characterized on the basis of their detailed spectral studies and were evaluated for their antimicrobial activities in two Gram-positive bacteria (Staphylococcus aureus, Bacillus subtillis) and two Gram-negative bacteria (Echerichia coli and Pseudomonas aeuroginosa) and two fungi (Aspergillusniger and Aspergillusfumigatus) strains using Cup plate method

引用

页码：645 / 652

页数：8

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