THERAPY OF PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS WITH INVOLVEMENT OF THE CENTRAL-NERVOUS-SYSTEM

The authors analyze the results of treatment of 35 patients with verified systemic lupus erythematosus (SLE) with sluggish-neuropsychic disorders, making use of prolonged therapy with prednisolone and cyclophosphamide. Clinical involvement of the central nervous system was characterized by various symptoms, for whose objective evaluation present-day examination modalities were employed, including computer-aided tomography of the brain. Improvement was seen in 57.6 % of patients in a month after the treatment was started, in 4 years 61.3 % of patients felt better. A clinical example is presented, illustrating the efficacy of prolonged treatment with cyclophosphamide of a female patient with SLE and CNS involvement.