RECOMBINANT HUMAN SUPEROXIDE-DISMUTASE CAN ATTENUATE ISCHEMIC NEURONAL DAMAGE IN GERBILS

被引：33
|
作者：
TAGAYA, M
MATSUMOTO, M
KITAGAWA, K
NIINOBE, M
OHTSUKI, T
HATA, R
OGAWA, S
HANDA, N
MIKOSHIBA, K
KAMADA, T
机构：
[1] OSAKA UNIV,SCH MED,DEPT INTERNAL MED 1,1-1-50 FUKUSHIMA,FUKUSHIMA KU,OSAKA 553,JAPAN
[2] OSAKA UNIV,INST PROT RES,DIV REGULAT MACROMOLEC FUNCT,SUITA,OSAKA 565,JAPAN
来源：
LIFE SCIENCES | 1992年 / 51卷 / 04期
关键词：
D O I：
10.1016/0024-3205(92)90083-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.
引用
收藏
页码：253 / 259
页数：7
相关论文
共 50 条
  • [41] HUMAN RECOMBINANT SUPEROXIDE-DISMUTASE PROTECTS PRIMARY CULTURED NEURONS AGAINST HYPOXIC INJURY
    KINOSHITA, A
    YAMADA, K
    KOHMURA, E
    HAYAKAWA, T
    PATHOBIOLOGY, 1991, 59 (05) : 340 - 344
  • [42] LOCALIZATION OF FLUORESCENTLY LABELED RECOMBINANT HUMAN SUPEROXIDE-DISMUTASE (RHSOD) FOLLOWING INTRATRACHEAL (IT) ADMINISTRATION
    SAHGAL, N
    SIMON, SR
    ROBBINS, CG
    LANGENBACK, EG
    HOROWITZ, S
    COLFLESH, D
    PERRY, R
    DAVIS, JM
    PEDIATRIC RESEARCH, 1995, 37 (04) : A348 - A348
  • [43] REDUCTION IN EXPERIMENTAL INFARCT SIZE BY RECOMBINANT HUMAN SUPEROXIDE-DISMUTASE ADMINISTRATION DURING REPERFUSION
    AMBROSIO, G
    BECKER, LC
    HUTCHINS, GM
    WEISFELDT, ML
    CIRCULATION, 1985, 72 (04) : 351 - 351
  • [44] A CALORIMETRIC STUDY OF HUMAN CUZN SUPEROXIDE-DISMUTASE
    BILIADERIS, CG
    WESELAKE, RJ
    PETKAU, A
    FRIESEN, AD
    BIOCHEMICAL JOURNAL, 1987, 248 (03) : 981 - 984
  • [45] EFFICACY OF RECOMBINANT HUMAN MANGANESE SUPEROXIDE-DISMUTASE COMPARED TO ALLOPURINOL IN PROTECTION OF ISCHEMIC SKELETAL-MUSCLE AGAINST NO-REFLOW
    OFARRELL, D
    CHEN, LE
    SEABER, AV
    MURRELL, GAC
    URBANIAK, JR
    JOURNAL OF RECONSTRUCTIVE MICROSURGERY, 1995, 11 (03) : 207 - 214
  • [46] SUPEROXIDE-DISMUTASE AMELIORATES NEURONAL DEATH FROM HYPOXIA IN CULTURE
    ROSENBAUM, DM
    KALBERG, J
    KESSLER, JA
    STROKE, 1994, 25 (04) : 857 - 863
  • [47] SUPEROXIDE-DISMUTASE ACTIVITY OF HUMAN GRANULOCYTES AND LYMPHOCYTES
    KOBAYASHI, Y
    ISHIGAME, K
    ISHIGAME, Y
    USUI, T
    LANCET, 1977, 1 (8016): : 865 - 866
  • [48] IMMUNOHISTOCHEMICAL LOCALIZATION OF SUPEROXIDE-DISMUTASE IN THE HUMAN OVARY
    SHIOTANI, M
    NODA, Y
    NARIMOTO, K
    IMAI, K
    MORI, T
    FUJIMOTO, K
    OGAWA, K
    HUMAN REPRODUCTION, 1991, 6 (10) : 1349 - 1353
  • [49] PHARMACOLOGICAL INTERACTIONS OF EXOGENOUS LUNG SURFACTANT AND RECOMBINANT HUMAN CU ZN SUPEROXIDE-DISMUTASE
    DAVIS, JM
    ROSENFELD, WN
    KOO, HC
    GONENNE, A
    PEDIATRIC RESEARCH, 1994, 35 (01) : 37 - 40
  • [50] RADIOIMMUNE ASSAY FOR HUMAN SUPEROXIDE-DISMUTASE IN ERYTHROCYTES
    DELVILLANO, BC
    TISCHFIELD, JA
    FEDERATION PROCEEDINGS, 1978, 37 (06) : 1749 - 1749
12345