SYNTHESIS OF SOME 2-HETEROCYCLYL-5-NITROTHIAZOLES AS POTENTIAL ANTHELMINTICS

被引：0
|
作者：
SAWHNEY, SN [1 ]
GUPTA, A [1 ]
SHARMA, PK [1 ]
RASHMI, N [1 ]
机构：
[1] KURUKSHETRA UNIV, DEPT CHEM, KURUKSHETRA 132119, HARYANA, INDIA
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1991年 / 30卷 / 06期
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D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Three series of 5-nitrothiazoles, namely 2-(3,5-dimethylpyrazol-l-yl)-5-nitrothiazoles (I), 2-(5-amino-3-arylpyrazol-l-yl-5-nitrothiazoles (II) and 2-(5-nitrothiazol-2-yl)-6-aryl-4,5-dihydro-3(2H)-pyridazinones (III) and their 4-methyl analogues have been synthesized as potential anthelmintics by treatment of 2-hydrazino-5-nitrothiazoles with pentane-2,4-diones, alpha-cyanoacetophenones and beta-aroylpropionic acids, respectively. None of the nine selected compounds tested shows any significant activity against N. brasiliensis and H. nana in mice at 250 mg/kg x 3 days. Some of the compounds, however, show high antifungal activity.
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页码：589 / 594
页数：6
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