CD43 DIMINISHES SUSCEPTIBILITY TO T LYMPHOCYTE-MEDIATED CYTOLYSIS

被引:0
|
作者
MCFARLAND, TA [1 ]
ARDMAN, B [1 ]
MANJUNATH, N [1 ]
FABRY, JA [1 ]
LIEBERMAN, J [1 ]
机构
[1] TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED,DIV HEMATOL ONCOL,BOSTON,MA 02111
来源
JOURNAL OF IMMUNOLOGY | 1995年 / 154卷 / 03期
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
CD43 is a major membrane sialoglycoprotein expressed by cells of hematopoietic origin. One property of CD43 is its ability to interfere with heterotypic and homotypic cellular adhesion. To determine whether CD43 expression can affect cell functions requiring intercellular adhesion, we compared a CD43-positive human T cell line (CEM) and its CD43-negative counterpart derived by gene targeting for susceptibility to cell-mediated lysis. CD43-negative CEM cells were more susceptible than CD43-positive cells to lysis by allospecific T cell lines derived from several donors. Induction of CD43 expression on transfected HeLa cells also imparted resistance to lectin-mediated lysis by a CD8(+) T cell clone. The effect of CD43 expression on reducing susceptibility to lysis was more pronounced in short-term cytotoxicity assays and tended to disappear as the time of contact between the effector cell and its target increased. The enhanced susceptibility of CD43-negative cells to lysis was not associated with increased expression of adhesion molecules known to mediate antigen-independent cellular adhesion. Sialic acid residues on CD43 contributed to the CD43 protective effect. These results suggest that either diminished CD43 expression or incomplete sialylation may render hematopoietic cells more susceptible to T lymphocyte-mediated cytolysis.
引用
收藏
页码:1097 / 1104
页数:8
相关论文
共 50 条
  • [21] THE MECHANISM OF LYMPHOCYTE-MEDIATED CYTOLYSIS VIEWED AS A STIMULATORY PROCESS OF THE TARGET
    BERKE, G
    TIROSH, R
    IMMUNOBIOLOGY, 1984, 167 (1-3) : 96 - 96
  • [22] LYMPHOCYTE-MEDIATED TUMOR CYTOLYSIS AFTER TREATMENT WITH IMMUNE RNA
    STEELE, G
    WANG, BS
    MANNICK, JA
    METHODS IN CANCER RESEARCH, 1982, 20 : 107 - 136
  • [23] Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis
    Hasegawa, Kana
    Tanaka, Satomi
    Fujiki, Fumihiro
    Morimoto, Soyoko
    Nakano, Katsuhiko
    Kinoshita, Hiroko
    Okumura, Atsushi
    Fujioka, Yuka
    Urakawa, Rika
    Nakajima, Hiroko
    Tatsumi, Naoya
    Nakata, Jun
    Takashima, Satoshi
    Nishida, Sumiyuki
    Tsuboi, Akihiro
    Oka, Yoshihiro
    Oji, Yusuke
    Miyoshi, Eiji
    Hirata, Takako
    Kumanogoh, Atsushi
    Sugiyama, Haruo
    Hosen, Naoki
    PLOS ONE, 2016, 11 (03):
  • [24] TARGETED DISRUPTION OF CD43 GENE ENHANCES T-LYMPHOCYTE ADHESION
    MANJUNATH, N
    JOHNSON, RS
    STAUNTON, DE
    PASQUALINI, R
    ARDMAN, B
    JOURNAL OF IMMUNOLOGY, 1993, 151 (03): : 1528 - 1534
  • [25] MECHANISM OF LYMPHOCYTE-MEDIATED CYTOLYSIS - FUNCTIONAL CYTOLYTIC T-CELLS LACKING PERFORIN AND GRANZYMES
    BERKE, G
    ROSEN, D
    RONEN, D
    IMMUNOLOGY, 1993, 78 (01) : 105 - 112
  • [26] INHIBITION OF LYMPHOCYTE-MEDIATED CYTOLYSIS BY 3-DEAZAADENOSINE - EVIDENCE FOR A METHYLATION REACTION ESSENTIAL TO CYTOLYSIS
    ZIMMERMAN, TP
    WOLBERG, G
    DUNCAN, GS
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (12) : 6220 - 6224
  • [27] THE ORIGIN AND ROLE OF RING-LIKE STRUCTURES IN LYMPHOCYTE-MEDIATED CYTOLYSIS
    BERKE, G
    ROSEN, D
    FEDERATION PROCEEDINGS, 1985, 44 (04) : 1285 - 1285
  • [28] LYMPHOCYTE-MEDIATED ANTIBODY-DEPENDENT CYTOLYSIS - ROLE IN IMMUNE HEMOLYSIS
    HANDWERGER, BS
    KAY, NE
    DOUGLAS, SD
    VOX SANGUINIS, 1978, 34 (05) : 276 - 280
  • [29] EVALUATION OF FREE-RADICAL SCAVENGERS IN STUDIES OF LYMPHOCYTE-MEDIATED CYTOLYSIS
    DEVLIN, RG
    LIN, CS
    PERPER, RJ
    DOUGHERTY, H
    IMMUNOPHARMACOLOGY, 1981, 3 (02): : 147 - 159
  • [30] TARGET-CELL CA-2+ IN LYMPHOCYTE-MEDIATED CYTOLYSIS
    BERKE, G
    RUBINSTEIN, I
    ROSEN, D
    BINAH, O
    FASEB JOURNAL, 1988, 2 (05): : A1238 - A1238