EFFECT OF PHORBOL 12-MYRISTATE 13-ACETATE (PMA) ON THE PHOSPHOINOSITOL (PI) SYSTEM IN TETRAHYMENA - STUDY OF THE P-32 INCORPORATION AND BREAKDOWN OF PHOSPHOLIPIDS

被引：10
|
作者：
KOVACS, P
CSABA, G
机构：
[1] Department of Biology, Semmelweis University of Medicine, Budapest
来源：
CELL BIOCHEMISTRY AND FUNCTION | 1995年 / 13卷 / 02期
关键词：
PHOSPHOINOSITOL SYSTEM; TETRAHYMENA; PHORBOL ESTER; 2ND-MESSENGERS;
D O I：
10.1002/cbf.290130204
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phorbol 12-myristate 13-acetate (PMA) treatment elicited an increased P-32 incorporation into phospholipids namely phosphatadyl-inositol (PI); phosphatidyl-inositol-4-phosphate (PIP); phosphatidyl-inositol-4,5-bis-phosphate (PIP2); phosphatidyl-acid (PA); phosphatidyl-choline (PC) and phosphatidyl-ethanolamine (PE) particularly at the 20-30th min after treatment. The ratio of members of the phosphoinositol system, especially PIP and PI, related to the total phospholipid content was increased. PMA (2 x 10(-7) M) was the most effective of the three concentrations tested. The results call attention to the presence of a working phosphoinositol system in Protozoa.
引用
收藏
页码：85 / 89
页数：5
相关论文
共 50 条
  • [31] Activation of Intracellular Protein Kinase C (PKC) Alpha by Phorbol 12-Myristate 13-Acetate (PMA) Induces CD36 Ectodomain Phosphorylation
    Chu, Ling-yun
    Silverstein, Roy
    CIRCULATION, 2011, 124 (21)
  • [32] Rapid killing of human neutrophils by the potent activator phorbol 12-myristate 13-acetate (PMA) accompanied by changes different from typical apoptosis or necrosis
    Takei, H
    Araki, A
    Watanabe, H
    Ichinose, A
    Sendo, F
    JOURNAL OF LEUKOCYTE BIOLOGY, 1996, 59 (02) : 229 - 240
  • [33] FREE-RADICAL DETECTION IN HUMAN T-CELL LINE FOLLOWING EXPOSURE TO TUMOR PROMOTOR PHORBOL 12-MYRISTATE 13-ACETATE (PMA)
    LANGE, DG
    BECKER, KG
    PHELAN, AM
    BIAS, W
    FEDERATION PROCEEDINGS, 1987, 46 (03) : 410 - 410
  • [34] PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INCREASES THE EXPRESSION OF THE NERVE GROWTH-FACTOR (NGF) GENE IN MOUSE L-929 FIBROBLASTS
    WION, D
    MACGROGAN, D
    HOULGATTE, R
    BRACHET, P
    FEBS LETTERS, 1990, 262 (01): : 42 - 44
  • [35] Activation of p44/42 by Phorbol 12-Myristate 13-Acetate (PMA) and Tributyltin (TBT) in Human Natural killer (NK) Cells Results in Loss of Cytotoxic Function
    Dudimah, Fred Duafalia
    Whalen, Margaret
    FASEB JOURNAL, 2008, 22
  • [36] THE PHORBOL 12-MYRISTATE 13-ACETATE (PMA)-INDUCED OXIDATIVE BURST IN RAT PERITONEAL NEUTROPHILS IS INCREASED BY A 0.1 MT (60 HZ) MAGNETIC-FIELD
    ROY, S
    NODA, Y
    ECKERT, V
    TRABER, MG
    MORI, A
    LIBURDY, R
    PACKER, L
    FEBS LETTERS, 1995, 376 (03) : 164 - 166
  • [37] Identification of regulatory elements involved in insulin and phorbol 12-myristate 13-acetate (PMA) effect on the cholesterol 7α-hydroxylase (CYP7A1) gene expression.
    Sadeghpour, A
    Crestani, M
    Chiang, JYL
    FASEB JOURNAL, 1999, 13 (07): : A1465 - A1465
  • [38] Phorbol 12-myristate 13-acetate (PMA) induced ear inflammation in transient receptor potencial vanilloid 1 (TRPV1) receptor transgenic mice
    Pozsgai, Gabor
    Sandor, Katalin
    Perkecz, Aniko
    Szolcsanyi, Janos
    Pinter, Erika
    ACTA PHARMACOLOGICA SINICA, 2006, 27 : 111 - 111
  • [39] Effect of immunosuppressive drugs on cytokine production in canine whole blood stimulated with lipopolysaccharide or a combination of ionomycin and phorbol 12-myristate 13-acetate
    Dandrieux, Julien R. S.
    Narayanan, Lakshmi
    Firestone, Simon
    Archer, Todd M.
    Mansfield, Caroline S.
    VETERINARY MEDICINE AND SCIENCE, 2019, 5 (02) : 199 - 205
  • [40] Effect of Phorbol 12-Myristate 13-Acetate on Function and Gene Expression of P-Glycoprotein in Adriamycin-Resistant K562/ADM Cells
    Li, Yuhua
    Bi, Huichang
    Zhong, Guoping
    Huang, Ling
    Li, Gelin
    Xia, Yanzhe
    Chen, Xiao
    Huang, Min
    PHARMACOLOGY, 2013, 92 (3-4) : 121 - 130
12345