ABNORMAL ISOFORM OF PRION PROTEIN ACCUMULATES IN FOLLICULAR DENDRITIC CELLS IN MICE WITH CREUTZFELDT-JAKOB DISEASE

被引：256

作者：

KITAMOTO, T ^{[1
]}

MURAMOTO, T ^{[1
]}

MOHRI, S ^{[1
]}

DOHURA, K ^{[1
]}

TATEISHI, J ^{[1
]}

机构：

[1] KYUSHU UNIV, FAC MED, CTR LAB ANIM, FUKUOKA 812, JAPAN

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 11期

关键词：

D O I：

10.1128/JVI.65.11.6292-6295.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We established that follicular dendritic cells (FDCs) are the site of abnormal prion protein (PrP(CJD)) accumulations in lymphoid tissues from mice infected with Creutzfeldt-Jakob disease. Evidence of positive FDC staining was observed in Creutzfeldt-Jakob disease-infected mice irrespective of the inoculation route, while no such staining was seen in the control mice. We also found that the severe combined immunodeficiency mouse trait is transmittable via the intracranial route but not via the intraperitoneal route. Mice with severe combined immunodeficiency did not have PrP(CJD) accumulation in FDCs.

引用

页码：6292 / 6295

页数：4

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