CIRCULAR-DICHROISM DETECTION IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY - EVALUATION OF THE ANISOTROPY FACTOR

被引：16
|
作者：
BERTUCCI, C [1 ]
DOMENICI, E [1 ]
SALVADORI, P [1 ]
机构：
[1] UNIV PISA,CTR STUDIO MACROMOLEC STEREORDINATE & OTTICAMENTE ATTIVE,CNR,I-56126 PISA,ITALY
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1990年 / 8卷 / 8-12期
关键词：
CIRCULAR DICHROISM; LIQUID CHROMATOGRAPHY DETECTION SYSTEM; CHIRAL DISCRIMINATION; DRUG ANALYSIS; STEREOCHEMISTRY; PIRKLE PHASE; G-FACTOR; ENANTIOMERIC EXCESS; PREPARATIVE LC;
D O I：
10.1016/0731-7085(90)80130-H
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The application of a circular dichroism (c.d.) detection system in HPLC using a chiral stationary phase is presented. The simultaneous measurement of the absorbance and c.d. signal allows the evaluation of the anisotropy factor (g = DELTA-epsilon/epsilon) and thus the determination of the enantiomeric excess (e.e.) of the eluates. When this detection system is used in preparative chiral chromatography the collection of the enantiomeric fractions can be readily optimized.
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页码：843 / 846
页数：4
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