A COMPARISON OF THE INVITRO ACTIVITY OF CLARITHROMYCIN, A NEW MACROLIDE ANTIBIOTIC, WITH ERYTHROMYCIN AND OTHER ORAL-AGENTS

被引：2
|
作者：
KING, A
PHILLIPS, I
机构：
[1] Department of Microbiology, UMDS, St. Thomas' Hospital, London
来源：
JOURNAL OF HOSPITAL INFECTION | 1991年 / 19卷
关键词：
CLARITHROMYCIN; BACTERIAL SUSCEPTIBILITY; INVITRO TESTS;
D O I：
10.1016/0195-6701(91)90212-Q
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
On the basis of minimum inhibitory concentrations clarithromycin (6-O-methylerythromycin), a new macrolide, was found to be slightly more active than erythromycin against Staphylococcus aureus, enterococci. Moraxella catarrhalis, Gardnerella vaginalis, Bacteroides fragilis (sensu stricto) and B. ureolyticus and slightly less active against coagulase-negative staphylococci, α- and β-haemolytic streptococci, Haemophilus influenzae, Campylobacter coli/jejuni and the B. melaninogenicus/oralis groups. There was complete cross-resistance between the two agents. Reports of potentiation of the activity against Haemophilus influenzae of clarithromycin by its own metabolite and by human serum appear to operate in vivo, and therefore the new agent shows great promise, especially for the treatment of respiratory tract infections. © 1991.
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页码：3 / 9
页数：7
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