SYNTHESIS OF NOVEL ISOQUINOLINE DERIVATIVES AS POTENTIAL CNS-AGENTS

被引：34
|
作者：
BONNAUD, B
CARLESSI, A
BIGG, DCH
机构：
[1] Centre de Recherche Pierre Fabre, Castres, F-81106
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1993年 / 30卷 / 01期
关键词：
D O I：
10.1002/jhet.5570300144
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 4-aminomethyl-1,2,3,4-tetrahydroisoquinoline derivatives were prepared as potential CNS-agents acting via amino-acid neurotransmitter systems. The compounds were synthesized from 1,2,3,4-tetra-hydro-1-oxoisoquinoline-4-carboxylic acids obtained by dipolar cycloadditon reactions of imines with homophthalic anhydride. Among the compounds testes 5c and 5m showed sub-micromolar affinity for the NMDA receptor and represent a structurally novel class of ligand for this site.
引用
收藏
页码：257 / 265
页数：9
相关论文
共 50 条
  • [41] Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents
    Xiao-Fei Zhang
    Rong-qin Sun
    Yi-fan Jia
    Qing Chen
    Rong-Fu Tu
    Ke-ke Li
    Xiao-Dong Zhang
    Run-Lei Du
    Ri-hui Cao
    Scientific Reports, 6
  • [42] Synthesis and biological evaluation of novel demethylzeylasteral derivatives as potential anticancer agents
    Sun, Xiaojing
    Xing, Lin
    Yuan, Jieying
    Wang, Enxiao
    Ding, Yuxin
    Sheng, Ruilong
    Wang, Fang
    Wu, Wenhui
    Yang, Xiuwei H.
    Guo, Ruihua
    FITOTERAPIA, 2023, 167
  • [43] Design, Synthesis of Novel Thiourea and Pyrimidine Derivatives as Potential Antitumor Agents
    Abu-Hashem, Ameen A.
    Badria, Farid A.
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2015, 62 (06) : 506 - 512
  • [44] Synthesis and biological evaluation of novel withangulatin A derivatives as potential anticancer agents
    Zhou, Wu-Xi
    Chen, Chen
    Liu, Xiao-Qin
    Li, Ying
    Kong, Ling-Yi
    Luo, Jian-Guang
    BIOORGANIC CHEMISTRY, 2021, 108
  • [45] Synthesis and biological evaluation of novel aminoguanidine derivatives as potential antibacterial agents
    Bai, Xueqian
    Wang, Jinghan
    Jiao, Feitong
    Zhang, Hongmei
    Zhang, Tianyi
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [46] Synthesis and biological activity of novel benzimidazole derivatives as potential antifungal agents
    Si, Weijie
    Zhang, Tao
    Li, Yaofa
    She, Dongmei
    Pan, Wenliang
    Gao, Zhanlin
    Ning, Jun
    Mei, Xiangdong
    JOURNAL OF PESTICIDE SCIENCE, 2016, 41 (01) : 15 - 19
  • [47] Synthesis and Biological Evaluation of Novel Phenothiazine Derivatives as Potential Antitumor Agents
    Venkatesan, K.
    Satyanarayana, V. S. V.
    Sivakumar, A.
    POLYCYCLIC AROMATIC COMPOUNDS, 2023, 43 (01) : 850 - 859
  • [48] Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents
    Zhang, Xiao-Fei
    Sun, Rong-qin
    Jia, Yi-fan
    Chen, Qing
    Tu, Rong-Fu
    Li, Ke-ke
    Zhang, Xiao-Dong
    Du, Run-Lei
    Cao, Ri-hui
    SCIENTIFIC REPORTS, 2016, 6
  • [49] Synthesis and evaluation of novel triazolyl quinoline derivatives as potential antileishmanial agents
    Upadhyay, Akanksha
    Kushwaha, Pragati
    Gupta, Sampa
    Dodda, Ranga Prasad
    Ramalingam, Karthik
    Kant, Ruchir
    Goyal, Neena
    Sashidhara, Koneni V.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 154 : 172 - 181
  • [50] Synthesis and biological evaluation of novel acylhydrazone derivatives as potential antitumor agents
    Congiu, Cenzo
    Onnis, Valentina
    BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (21) : 6592 - 6599
12345