Lipomatous hypertrophy of the atrial septum (LHAS) is an infrequently observed entity characterized by an unencapsulated proliferation of mature and multivacuolated adipose tissue within the interatrial septum.1-3 It has been suggested that LHAS is associated with an increased incidence of supraventricular dysrhythmias, sudden death, obesity, abnormal P waves on electrocardiography, and advanced age.1-5 Whereas initial descriptions of this entity were from autopsy studies,1-3,5 in vivo diagnosis of LHAS has been described using transthoracic echocardiography (TTE).4,6-8 Recently, it was found that transesophageal echocardiography (TEE) may be superior to TTE in the detection of abnormalities associated with the atrial septum.9 Thus, we hypothesized that TEE would be a superior technique to detect LHAS in a referral population and would enable the characterization of a group of patients with this entity. © 1992.