PH+ ACUTE MYELOGENOUS LEUKEMIA WITH T(711)(P15P15) AND CLONAL EVOLUTION IN RELAPSE AFTER BONE-MARROW TRANSPLANTATION

被引：7
|
作者：
MIURA, I [1 ]
NISHINARI, T [1 ]
HASHIMOTO, K [1 ]
NIMURA, T [1 ]
TAKATSU, H [1 ]
NIITSU, H [1 ]
HIROKAWA, M [1 ]
KUWAYAMA, A [1 ]
NISHIMURA, S [1 ]
MIURA, AB [1 ]
机构：
[1] YURI KUMIAI GEN HOSP,DIV INTERNAL MED,AKITA,JAPAN
来源：
ACTA HAEMATOLOGICA | 1993年 / 90卷 / 03期
关键词：
BONE MARROW TRANSPLANTATION; PH+ ACUTE MYELOGENOUS LEUKEMIA AML; TRANSLOCATION T(711)(P15P15);
D O I：
10.1159/000204397
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 20-year-old female with Ph+ acute myelogenous leukemia (M2) associated with t(7;11)(p15;p15) is reported. Bone marrow aspirates were hypercellular with leukemic cells including Auer rods. Chromosome analysis showed t(7;11) and the Ph chromosome. After complete remission, normal karyotype was restored. Normal male karyotypic cells replaced the bone marrow following allogeneic bone marrow transplantation from her brother. On day 358, cytogenetic study at relapse revealed 14q+ as an additional change and clearly showed that the abnormal clone was derived from the patient, because metaphases with XX were all of abnormal karyotype and those with XY were normal.
引用
收藏
页码：148 / 150
页数：3
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