MURINE HYBRIDOMAS SECRETING MONOCLONAL-ANTIBODIES REACTING WITH MLS(A) ANTIGENS

被引：0
|
作者：
DEGIORGI, L [1 ]
DEMATOS, C [1 ]
ELLIS, BA [1 ]
MATOSSIANROGERS, A [1 ]
机构：
[1] ROYAL LONDON HOSP,COLL MED,DEPT IMMUNOL,LONDON,ENGLAND
来源：
EXPERIMENTAL AND CLINICAL IMMUNOGENETICS | 1993年 / 10卷 / 04期
关键词：
ANTI-SELF-ANTIBODY; MONOCLONAL ANTIIDIOTYPIC ANTIBODY; ANTI-MLS(A) ANTIBODY;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Murine monoclonal antibodies have been developed from spleens of AKR mice hyperimmunised with the monoclonal antibody against TCR-Vbeta6. Two new monoclonal antibodies called AL-12-3 and AL-32-7 were able to specifically block Mls(a)-induced but not MHC-induced mixed lymphocyte responses in a dose-dependent manner. Both antibodies are mouse IgG3 lambda chain isotype and bind to Mls(a)-bearing lymphocytes from different strains of mice. The availability of such antibodies may well facilitate future research aimed at immunochemical and molecular characterization of Mls de terminants.
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收藏
页码：219 / 223
页数：5
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