IMMUNOLOGICAL ANALYSIS OF ACQUIRED FACTOR-VIII INHIBITOR IN A CASE WITH IMMUNOLOGICAL DISORDER

被引：0
|
作者：
OKAMURA, T
YAMAUCHI, Y
FUKUDA, T
SUEHIRO, K
MURAKAWA, M
SHIBUYA, T
NAGASAWA, K
HARADA, M
NIHO, Y
机构：
来源：
ACTA HAEMATOLOGICA | 1991年 / 85卷 / 03期
关键词：
AUTOANTIBODY; FACTOR-VIII INHIBITOR; IGG SUBCLASS; POLYARTERITIS-NODOSA;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Coagulation factor VIII inhibitor arising in a patient with autoimmune disease was immunologically analyzed. A 63-year-old man who had been diagnosed as suffering from polyarteritis nodosa was treated with prednisolone for 10 years. Severe bleeding tendency developed and coagulation studies demonstrated a high titer of inhibitor to factor VIII:C. As a result of immunological analysis, the inhibitor was found to be IgG type autoantibody having both kappa and lambda-light chains. The subclasses were IgG1 and IgG4. The inhibitor recognized the COOH-terminal light chain (72-kDa thrombin fragment) on the factor VIII molecule as an epitope.
引用
收藏
页码：153 / 155
页数：3
相关论文
共 50 条
  • [41] IMMUNOLOGICAL AND VIROLOGICAL STUDIES IN HEMOPHILIC CHILDREN TREATED WITH FACTOR-VIII CONCENTRATES
    ARONIS, S
    MANDALENAKIS, A
    KALOGEROPULOS, K
    VRACHNOS, E
    LASKARIS, S
    KALLINIKOS, G
    TSIFTIS, G
    PAPAEVANGELOU, G
    EUROPEAN JOURNAL OF PEDIATRICS, 1985, 144 (01) : 110 - 110
  • [42] ABSENCE OF FACTOR-VIII AND IX ACTIVITIES IN A PATIENT DUE TO IMMUNOLOGICAL INHIBITORS
    MAMMEN, EF
    IRWIN, JF
    HILLMAN, CR
    HASSOUNA, HJ
    BISHOP, CR
    CLINICAL RESEARCH, 1975, 23 (02): : A132 - A132
  • [43] A RARE CASE OF FACTOR-VIII INHIBITOR FORMATION
    ECKSTEIN, A
    VOSS, B
    TAUBERT, W
    SCHEJA, J
    DEUTSCHE ZAHNARZTLICHE ZEITSCHRIFT, 1986, 41 (04): : 398 - 399
  • [44] INTRACEREBRAL HEMATOMA AND ACQUIRED FACTOR-VIII C-INHIBITOR
    MAHIEU, M
    LEMAHIEU, JM
    GUEVART, E
    LEDUC, JJ
    HOUVENAGEL, E
    CHOTEAU, P
    SEMAINE DES HOPITAUX, 1988, 64 (07): : 468 - 470
  • [45] ACQUIRED FACTOR-VIII INHIBITOR IN A PATIENT WITH MYCOSIS-FUNGOIDES
    WADDELL, CC
    LEHANE, DE
    ZUBLER, MA
    CANCER, 1981, 47 (12) : 2901 - 2903
  • [46] ACQUIRED FACTOR-VIII INHIBITOR IN JUVENILE RHEUMATOID-ARTHRITIS
    DEINOCENCIO, J
    LOVELL, DJ
    GABRIEL, CA
    PEDIATRICS, 1994, 94 (04) : 550 - 553
  • [47] SYNDROME OF AN ACQUIRED INHIBITOR OF FACTOR-VIII RESPONSIVE TO CYCLOPHOSPHAMIDE AND PREDNISONE
    HERBST, KD
    RAPAPORT, SI
    KENOYER, DG
    STANTON, W
    FEINSTEIN, DI
    ANNALS OF INTERNAL MEDICINE, 1981, 95 (05) : 575 - 578
  • [48] RETINAL SURGERY COMPLICATED BY A SPONTANEOUSLY ACQUIRED FACTOR-VIII INHIBITOR
    PRILUCK, IA
    HOWE, RB
    EIFRIG, DE
    EDSON, JR
    MILLER, K
    AMERICAN JOURNAL OF OPHTHALMOLOGY, 1978, 86 (01) : 27 - 30
  • [49] BIOCHEMICAL AND IMMUNOLOGICAL PROPERTIES OF AN ACQUIRED INHIBITOR OF FACTOR V
    FEINSTEIN, DI
    RAPAPORT, SI
    MCGEHEE, WG
    PATCH, MJ
    BLOOD-THE JOURNAL OF HEMATOLOGY, 1967, 30 (06): : 863 - +
  • [50] CARRIER DETECTION IN HEMOPHILIA-A BY IMMUNOLOGICAL MEASUREMENT OF FACTOR-VIII RELATED ANTIGEN (VIIIRAG) AND FACTOR-VIII CLOTTING ANTIGEN (VIIICAG)
    PEAKE, IR
    NEWCOMBE, RG
    DAVIES, BL
    FURLONG, RA
    LUDLAM, CA
    BLOOM, AL
    BRITISH JOURNAL OF HAEMATOLOGY, 1981, 48 (04) : 651 - 660
12345