ACUTE MEGAKARYOBLASTIC LEUKEMIA WITH TRANSLOCATION T(1-22)(P13-Q13) IN A 10-WEEK-OLD INFANT

被引：12
|
作者：
WASHIO, S
IDO, M
AZUMA, E
FUKUI, M
SHIBATA, T
ZHANG, SL
KOMADA, Y
ITO, M
KOIKE, T
KANEKO, Y
SAKURAI, M
机构：
[1] NIIGATA UNIV,SCH MED,DEPT INTERNAL MED 1,NIIGATA 95021,JAPAN
[2] SAITAMA CANC CTR,DEPT LAB,INA,SAITAMA 362,JAPAN
来源：
AMERICAN JOURNAL OF HEMATOLOGY | 1992年 / 39卷 / 01期
关键词：
C-SIS ONCOGENE; MYELOFIBROSIS; 1; 22; TRANSLOCATION;
D O I：
10.1002/ajh.2830390112
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 10-week-old girl without Down syndrome developed an acute megakaryoblastic leukemia (AMKL). Bone marrow aspirates and biopsy showed megakaryoblastic infiltration with myelofibrosis. The diagnosis was made based on the findings that the positive reactions of leukemic cells to platelet peroxidase and to monoclonal antibodies which recognize platelet-specific surface glycoprotein (GP) IIb/IIIa and GP78. The blasts also showed myeloid and monocytoid differentiation antigens. The leukemic cells had a karyotype of 46,XX,t(1;22)(p13;q13). Our case and two other infantile cases reported by other investigators establish the novel association of the t(1;22) with AMKL.
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收藏
页码：56 / 60
页数：5
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