DECREASED DENSITY OF BENZODIAZEPINE RECEPTORS IN LYMPHOCYTES OF ANXIOUS PATIENTS - REVERSAL AFTER CHRONIC DIAZEPAM TREATMENT

被引：78
|
作者：
FERRARESE, C
APPOLLONIO, I
FRIGO, M
PEREGO, M
PIOLTI, R
TRABUCCHI, M
FRATTOLA, L
机构：
[1] UNIV MILAN,OSPED SAN GERARDO TINTORI,DEPT NEUROL,NEUROL CLIN,VIA DONIZETTI 106,I-20052 MONZA,ITALY
[2] UNIV ROME,DEPT EXPTL MED,I-00100 ROME,ITALY
来源：
ACTA PSYCHIATRICA SCANDINAVICA | 1990年 / 82卷 / 02期
关键词：
anxiety disorder; diazepam; lymphocyte; peripheral benzodiazepine receptor;
D O I：
10.1111/j.1600-0447.1990.tb01376.x
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Peripheral‐type benzodiazepine receptors were measured in human circulating lymphocytes using 3H‐PK 11195 as specific ligand. In a group of outpatients with anxiety disorders a significant decrease of receptor density (– 37%) was found compared with age‐matched controls. In these patients long‐term diazepam treatment restored binding density to normal levels: the effect persisted after drug withdrawal. Acute i.v. diazepam administration did not change receptor density. The observed receptor changes could reflect a down‐regulation phenomenon and indicate that lymphocyte function reflect central nervous events. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码：169 / 173
页数：5
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