IGG AUTOANTIBODIES AGAINST C1Q ARE CORRELATED WITH NEPHRITIS, HYPOCOMPLEMENTEMIA, AND DSDNA ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：0

作者：

SIEGERT, C ^{[1
]}

DAHA, M ^{[1
]}

WESTEDT, ML ^{[1
]}

VANDERVOORT, E ^{[1
]}

BREEDVELD, F ^{[1
]}

机构：

[1] UNIV HOSP LEIDEN,DEPT NEPHROL,2300 RC LEIDEN,NETHERLANDS

来源：

JOURNAL OF RHEUMATOLOGY | 1991年 / 18卷 / 02期

关键词：

C1Q ANTIBODIES; LUPUS NEPHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the association between serum titers of IgG antibodies against Clq (ClqAb) and clinical and laboratory variables of disease activity in systemic lupus erythematosus (SLE). ClqAb were measured by ELISA in serum samples of 88 patients. Thirty patients (34%) had increased ClqAb titers. No correlation between ClqAb titers and a score for general disease activity was found. However, significant positive correlations were found between ClqAb titers and the presence of several clinical and laboratory variables of disease activity. These included nephritis, dermatitis, hypocomplementemia, antibodies against dsDNA, and circulating immune complexes. A negative correlation was found with neurological disease manifestations. The correlations between ClqAb titers and clinical features indicate that the pathogenetic role for ClqAb in certain disease manifestations of SLE deserves further study.

引用

页码：230 / 234

页数：5

共 50 条

[31] COMPARISON OF AUTOANTIBODIES TO THE COLLAGEN-LIKE REGION OF C1Q IN HYPOCOMPLEMENTEMIC URTICARIAL VASCULITIS SYNDROME AND SYSTEMIC LUPUS-ERYTHEMATOSUS
WISNIESKI, JJ
JONES, SM
JOURNAL OF IMMUNOLOGY, 1992, 148 (05): : 1396 - 1403
[32] AUTOANTIBODIES AGAINST PROTEIN AA IN SYSTEMIC LUPUS-ERYTHEMATOSUS
LINKE, RP
STOLLE, W
IMMUNOBIOLOGY, 1984, 168 (1-2) : 83 - 83
[33] Pediatric systemic lupus erythematosus with C1q deficiency
Kallel-Sellami, Maryam
Baili-Klila, Lilia
Zerzeri, Yousr
Laadhar, Lilia
Blouin, Jacques
Abdelmoula, Mohamed Slim
Zitouni, Mondher
Fremeaux-Bacchi, Veronique
Ben Dridi, Marie France
Makni, Sondes
AUTOIMMUNITY, PT D: AUTOIMMUNE DISEASE, ANNUS MIRABILIS, 2007, 1108 : 193 - 196
[34] THE C1Q BINDING ASSAY IN SYSTEMIC LUPUS-ERYTHEMATOSUS - DISCORDANCE WITH DISEASE-ACTIVITY
INMAN, RD
FONG, JKK
PUSSELL, BA
RYAN, PJ
HUGHES, GRV
ARTHRITIS AND RHEUMATISM, 1980, 23 (11): : 1282 - 1286
[35] C1q Deficiency and Neuropsychiatric Systemic Lupus Erythematosus
van Schaarenburg, Rosanne A.
Magro-Checa, Cesar
Bakker, Jaap A.
Teng, Y. K. Onno
Bajema, Ingeborg M.
Huizinga, Tom W.
Steup-Beekman, Gerda M.
Trouw, Leendert A.
FRONTIERS IN IMMUNOLOGY, 2016, 7
[36] ANTIPHOSPHOLIPID ANTIBODIES IN SYSTEMIC LUPUS-ERYTHEMATOSUS - EVIDENCE OF AN ASSOCIATION WITH POSITIVE COOMBS AND HYPOCOMPLEMENTEMIA
HAZELTINE, M
RAUCH, J
DANOFF, D
ESDAILE, JM
TANNENBAUM, H
JOURNAL OF RHEUMATOLOGY, 1988, 15 (01) : 80 - 86
[37] IMMUNOFLUORESCENCE METHOD IN MEASURING ANTI-DSDNA ANTIBODIES CORRELATED WITH VARIOUS MANIFESTATIONS OF SYSTEMIC LUPUS-ERYTHEMATOSUS
GOLAN, D
GILHAR, A
WOLF, V
ISRAEL JOURNAL OF MEDICAL SCIENCES, 1979, 15 (02): : 180 - 180
[38] C1q rs292001 polymorphism and C1q antibodies in juvenile lupus and their relation to lupus nephritis
Mosaad, Y. M.
Hammad, A.
Fawzy, Z.
El-Refaaey, A.
Tawhid, Z.
Hammad, E. M.
Youssef, L. F.
ElAttar, E. A. A.
Radwan, D. F.
Fawzy, I. M.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2015, 182 (01): : 23 - 34
[39] SYSTEMIC LUPUS-ERYTHEMATOSUS WITHOUT ANTINUCLEAR ANTIBODIES OR OTHER AUTOANTIBODIES
DUC, J
PERROULAZ, G
GOLAZ, J
CAMPICHE, M
PECOUD, A
SCHWEIZERISCHE MEDIZINISCHE WOCHENSCHRIFT, 1987, 117 (06) : 205 - 208
[40] STS-REACTIVE IGG ANTIBODIES AND ANTI-DSDNA ANTIBODIES IN THE SERA FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
NAGATA, N
MUSO, E
SEKITA, K
HAMASHIMA, Y
IRCS MEDICAL SCIENCE-BIOCHEMISTRY, 1985, 13 (11): : 1120 - 1121

← 1 2 3 4 5 →