WRNIP1: A new guardian of genome integrity at stalled replication forks

被引：3

作者：

Leuzzi, Giuseppe ^{[1
]}

Marabitti, Veronica ^{[1
]}

Pichierri, Pietro ^{[2
]}

Franchitto, Annapaola ^{[1
]}

机构：

[1] Ist Super Sanita, Sect Mol Epidemiol, Rome, Italy

[2] Ist Super Sanita, Dept Environm & Primary Prevent, Sect Expt & Computat Carcinogenesis, Rome, Italy

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 05期

关键词：

Genome instability; replication fork stalling; replication stress; WRNIP1;

D O I：

10.1080/23723556.2016.1215777

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Failure to protect and/or restart stalled replication forks contributes to genomic instability. Radiation-sensitive 51 (RAD51) recombinase defends stalled forks from nucleolytic attack, which otherwise can threaten their integrity. Recently, we have uncovered a novel and key function of Werner helicase interacting protein 1 (WRNIP1) as a fork-protective factor working in conjunction with RAD51 in response to replication stress.

引用

页数：2

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