WRNIP1: A new guardian of genome integrity at stalled replication forks

被引：3
|
作者：
Leuzzi, Giuseppe [1 ]
Marabitti, Veronica [1 ]
Pichierri, Pietro [2 ]
Franchitto, Annapaola [1 ]
机构：
[1] Ist Super Sanita, Sect Mol Epidemiol, Rome, Italy
[2] Ist Super Sanita, Dept Environm & Primary Prevent, Sect Expt & Computat Carcinogenesis, Rome, Italy
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 05期
关键词：
Genome instability; replication fork stalling; replication stress; WRNIP1;
D O I：
10.1080/23723556.2016.1215777
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Failure to protect and/or restart stalled replication forks contributes to genomic instability. Radiation-sensitive 51 (RAD51) recombinase defends stalled forks from nucleolytic attack, which otherwise can threaten their integrity. Recently, we have uncovered a novel and key function of Werner helicase interacting protein 1 (WRNIP1) as a fork-protective factor working in conjunction with RAD51 in response to replication stress.
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页数：2
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