STRUCTURE OF MICROCIN C51, A NEW ANTIBIOTIC WITH A BROAD-SPECTRUM OF ACTIVITY

被引：30
|
作者：
METLITSKAYA, AZ
KATRUKHA, GS
SHASHKOV, AS
ZAITSEV, DA
EGOROV, TA
KHMEL, IA
机构：
[1] RUSSIAN ACAD MED SCI,INST NEW ANTIBIOT,MOSCOW 119867,RUSSIA
[2] RUSSIAN ACAD SCI,ND ZELINSKII ORGAN CHEM INST,MOSCOW 117334,RUSSIA
[3] RUSSIAN ACAD MED SCI,VA ENGELHARDT MOLEC BIOL INST,MOSCOW 117984,RUSSIA
来源：
FEBS LETTERS | 1995年 / 357卷 / 03期
关键词：
MICROCIN; PEPTIDE ANTIBIOTIC; NUCLEOTIDE PEPTIDE;
D O I：
10.1016/0014-5793(94)01345-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The structure of microcin C51, a new antibiotic produced by E. coli, has been determined. This antibiotic was shown to be a 1.18 kDa nucleotide peptide. It consists of a heptapeptide with formylmethionine as the N-terminus and a C-terminal asparagine linked with nebularin-5'-monophosphate through the three-methylene bridge. The OH-group of threonine is substituted. The peptide chain of microcin C51 synthesized on ribosomes is the longest among the known biologically active nucleotide peptides.
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页码：235 / 238
页数：4
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