A TRANSCRIPTION MAP OF THE REGION CONTAINING THE HUNTINGTON DISEASE GENE

被引：40
|
作者：
ROMMENS, JM
LIN, B
HUTCHINSON, GB
ANDREW, SE
GOLDBERG, YP
GLAVES, ML
GRAHAM, R
LAI, V
MCARTHUR, J
NASIR, J
THEILMANN, J
MCDONALD, H
KALCHMAN, M
CLARKE, LA
SCHAPPERT, K
HAYDEN, MR
机构：
[1] UNIV BRITISH COLUMBIA,DEPT MED GENET,416-2125 E MALL,NCE BLDG,VANCOUVER V6T 1Z4,BC,CANADA
[2] HOSP SICK CHILDREN,DEPT GENET,TORONTO M5G 1X8,ONTARIO,CANADA
来源：
HUMAN MOLECULAR GENETICS | 1993年 / 2卷 / 07期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1093/hmg/2.7.901
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A transcription map of the Huntington disease gene region was generated by a direct cDNA selection strategy using genomic DNA from the 4p16.3 region surrounding the D4S95 and D4S127 loci. A total of 58 cDNA fragments were obtained from cDNAs derived from fetal brain, frontal cortex, liver and bone marrow following hybridization to overlapping YACs from this region. These cDNA clones were aligned into transcription units by hybridization to specific mRNAs, by sequence overlap and by physical mapping onto overlapping YAC clones. Nine separate transcription units spanning approximately one megabase were detected by RNA hybridization. They represent a minimum number of genes in this region and do not include those genes expressed specifically in tissues not used for the hybridization. The transcription map that is provided by the cDNA segments will lead to the generation of a detailed gene map of this region.
引用
收藏
页码：901 / 907
页数：7
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