A SMAI PCR-RFLP IN THE 5' NONCODING REGION OF THE HUMAN D4 DOPAMINE-RECEPTOR GENE (DRD4)

被引：19
|
作者：
PETRONIS, A
VANTOL, HHM
KENNEDY, JL
机构：
[1] CLARKE INST PSYCHIAT,NEUROGENET SECT,TORONTO M5T 1R8,ON,CANADA
[2] CLARKE INST PSYCHIAT,MOLEC NEUROBIOL LAB,TORONTO,ON,CANADA
[3] UNIV TORONTO,TORONTO,ON,CANADA
来源：
HUMAN HEREDITY | 1994年 / 44卷 / 01期
关键词：
RESTRICTION FRAGMENT LENGTH POLYMORPHISM; GENES; HUMAN;
D O I：
10.1159/000154191
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The D4 dopamine receptor is of great interest for research into neuropsychiatric disorders and psychopharmacology in light of the fact that it binds the antipsychotic medication clozapine with higher affinity than does any other dopamine receptor [Van Tol, et al., Nature 1991;350:610-614]. Furthermore, in the third exon of this gene, there is an unusual 48-bp repeat sequence polymorphism that produces variable receptor protein sequences that have different affinities for the drug clozapine [Van Tol, et al., Nature 1992;358:149-152]. A new two-allele PCR-based SmaI restriction fragment length polymorphism (RFLP) was revealed at the human DRD4 locus employing a new method for the detection of PCR-able RFLPs. The polymorphic SmaI restriction site is located in the 5' noncoding region of the human DRD4 gene. This SmaI PCR-RFLP serves as an additional marker for genetic linkage and association studies between DRD4 and neuropsychiatric disorders.
引用
收藏
页码：58 / 60
页数：3
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