BIOLOGICALLY-ACTIVE CONSTITUENTS OF CENTIPEDA-MINIMA - SESQUITERPENES OF POTENTIAL ANTIALLERGY ACTIVITY

被引：1

作者：

WU, JB ^{[1
]}

CHUN, YT ^{[1
]}

EBIZUKA, Y ^{[1
]}

SANKAWA, U ^{[1
]}

机构：

[1] UNIV TOKYO, FAC PHARMACEUT SCI, 7-3-1 HONGO, BUKYO KU, TOKYO 113, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 12期

关键词：

CENTIPEDA-MINIMA; COMPOSITAE; SESQUITERPENE LACTONE; SENECIOYLPLENOLIN; ISOBUTYROYLPLENOLIN; AURATIAMIDE ACETATE; QUERCETIN METHYL ETHER; ANTIALLERGY; MAST CELL; PCA;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ether, methanol and aqueous extracts of Centipeda minima (Compositae) herbs were found to have significant anti-allergy activities in passive cutaneous anaphylaxis (PCA) test. Three flavonoids, two sesquiterpene lactones and an amide were isolated from this plant material as inhibitors to induced histamine release from mast cells. The sesquiterpenes were identified as isobutyroylplenolin and senecioylplenolin by spectral investigations. The flavonoids and sesquiterpenes exhibited significant anti-allergy activity in PCA test with p.o. administration.

引用

页码：3272 / 3275

页数：4

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