VINPOCETIN PROTECTS AGAINST EXCITOTOXIC CELL-DEATH IN PRIMARY CULTURES OF RAT CEREBRAL-CORTEX

被引：37

作者：

ERDO, SL ^{[1
]}

NINGSHENG, C ^{[1
]}

WOLFF, JR ^{[1
]}

KISS, B ^{[1
]}

机构：

[1] GEDEON RICHTER CHEM WORKS LTD,CHEM WORKS,PHARMACOL RES CTR,DIV BIOCHEM,H-1475 BUDAPEST,HUNGARY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 187卷 / 03期

关键词：

Cerebrocortical cultures; Excitotoxic cell death; Glutamate; Kainate; NMDA (N-methyl-D-aspartate); Quisqualate; Vinpocetin;

D O I：

10.1016/0014-2999(90)90386-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The protective effect of vinpocetin, a drug clinically useful in brain hypoxia/ischemia, was examined in vitro on cerebrocortical cultures treated with glutamate and related excitotoxins. The extent of cell death was quantified by measuring lactic dehydrogenase activity released from damaged cells into the culture medium. Vinpocetin partially protected the cortical cells against cell death induced by N-methyl-D-aspartate, quisqualate and kainate, indicating that the drug exerts a direct protective action on cerebrocortical cells bearing excitatory amino acid receptors. © 1990.

引用

页码：551 / 553

页数：3

共 50 条

[21] EXTRACELLULAR ADENOSINE IS NOT ACCUMULATED IN EXPLANT CULTURES OF RAT CEREBRAL-CORTEX
DAHNKE, HG
GIESING, M
HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1979, 360 (03): : 247 - 248
[22] DELTA AND KAPPA-OPIATE RECEPTORS IN PRIMARY ASTROGLIAL CULTURES FROM RAT CEREBRAL-CORTEX
ERIKSSON, PS
HANSSON, E
RONNBACK, L
NEUROCHEMICAL RESEARCH, 1990, 15 (11) : 1123 - 1126
[23] FORMATION OF CELL COLONIES IN CULTURES FROM MOUSE CEREBRAL-CORTEX
FEDOROFF, S
JUURLINK, B
HERTZ, L
OTERUELO, F
IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION, 1977, 13 (03): : 154 - 155
[24] HALOPERIDOL PARTIALLY PROTECTS AGAINST CELL-DEATH PRODUCED BY KETAMINE
SHARP, FR
NICKOLENKO, J
BUTMAN, M
CHANG, JM
NAKKI, R
SAGAR, SM
ANNALS OF NEUROLOGY, 1994, 36 (02) : 297 - 297
[25] NEURON GENERATION IN DISSOCIATED CELL-CULTURES FROM FETAL-RAT CEREBRAL-CORTEX
KRIEGSTEIN, A
DICHTER, MA
BRAIN RESEARCH, 1984, 295 (01) : 184 - 189
[26] AMYLOID PRECURSOR PROTEIN EXPRESSION AND LOCALIZATION IN RAT CEREBRAL-CORTEX CULTURES
TRESSER, N
PERRY, G
RICHEY, P
GAMBETTI, P
LEBLANC, A
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1993, 52 (03): : 307 - 307
[27] AN IMPROVED EPTA STAINING METHOD FOR SYNAPSES IN RAT CEREBRAL-CORTEX CULTURES
VANHUIZEN, F
ROMIJN, HJ
JOURNAL OF NEUROSCIENCE METHODS, 1985, 14 (04) : 267 - 271
[28] INTRACELLULAR ACIDOSIS PROTECTS AGAINST CELL-DEATH IN ISOLATED RAT HEPATOCYTES DURING CHEMICAL HYPOXIA
GORES, GJ
NIEMINEN, AL
HERMAN, B
LEMASTERS, JJ
HEPATOLOGY, 1987, 7 (05) : 1027 - 1027
[29] THE PRESENCE OF GLUTATHIONE IN PRIMARY NEURONAL AND ASTROGLIAL CULTURES FROM RAT CEREBRAL-CORTEX AND BRAIN-STEM
PILEBLAD, E
ERIKSSON, PS
HANSSON, E
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1991, 86 (01) : 43 - 49
[30] EFFECTS OF CEREBRO-PROTECTIVE AGENTS ON ENZYME-ACTIVITIES OF RAT PRIMARY GLIAL CULTURES AND RAT CEREBRAL-CORTEX
BIELENBERG, GW
HAYN, C
KRIEGLSTEIN, J
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (16) : 2693 - 2702

← 1 2 3 4 5 →