NEUTRALIZING ANTIBODY TO MENGO-VIRUS, INDUCED BY SYNTHETIC PEPTIDES

被引：14
|
作者：
MUIR, S
WEINTRAUB, JP
HOGLE, J
BITTLE, JL
机构：
来源：
JOURNAL OF GENERAL VIROLOGY | 1991年 / 72卷
关键词：
D O I：
10.1099/0022-1317-72-5-1087
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A peptide from the carboxyl-terminal region of the Mengo virus capsid protein VP1, representing residues 259 to 277, can induce serum neutralizing (SN) antibodies in both the mouse and guinea-pig. This peptide, termed F164, also induces high levels of protective neutralizing antibodies in mice subsequent to immunization; 87 to 100% of mice are refractory to the effects of an intraperitoneal challenge of 100 LD50 of Mengo virus. The mouse model discussed herein will prove useful for studying the immune response to Mengo virus and evaluating the immunogenicity of individual viral components.
引用
收藏
页码：1087 / 1092
页数：6
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