A TRUNCATED ACTIVIN RECEPTOR INHIBITS MESODERM INDUCTION AND FORMATION OF AXIAL STRUCTURES IN XENOPUS EMBRYOS

被引：497
|
作者：
HEMMATIBRIVANLOU, A
MELTON, DA
机构：
[1] Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138
来源：
NATURE | 1992年 / 359卷 / 6396期
关键词：
D O I：
10.1038/359609a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Activins can induce mesoderm in embryonic explants and have been proposed as the natural inducer in Xenopus. A mutant activin receptor that inhibits activin signalling is used to show that activin is required for the induction of mesoderm in vivo and the patterning of the embryonic body plan. Blocking the activin signal transduction pathway also reveals autonomous induction of a neural marker and unmasks a relationship between activin and fibroblast growth factor.
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页码：609 / 614
页数：6
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