LACK OF MUTATIONS OF THE P53 TUMOR SUPPRESSOR GENE IN HEPATOCELLULAR CARCINOMAS INDUCED IN RATS BY A PEROXISOME PROLIFERATOR

被引：23
|
作者：
SMITH, ML
YELESWARAPU, L
LOMBARDI, B
SHINOZUKA, H
机构：
[1] UNIV PITTSBURGH,SCH MED,DEPT PATHOL,PITTSBURGH,PA 15261
[2] UNIV PITTSBURGH,PITTSBURGH CANC INST,PITTSBURGH,PA 15261
来源：
MOLECULAR CARCINOGENESIS | 1993年 / 7卷 / 02期
关键词：
BR931; HEPATOCARCINOGENESIS; P53; SEQUENCING;
D O I：
10.1002/mc.2940070206
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Immunohistochemical, immunoblotting, and DNA-sequencing analyses were performed on hepatocellular carcinomas induced in rats chronically fed BR931, a peroxisome proliferator, to determine whether the tumors carried mutations or other alterations of the p53 gene. None were detected. in activation of this tumor suppressor gene does not appear, therefore, to be involved in the carcinogenicity of BR931, a nongenotoxic chemical hepAtocarcinogen.
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页码：89 / 93
页数：5
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