EFFECTS OF BOMBESIN ON THE DEVELOPMENT OF N-NITROSOBIS(2-OXOPROPYL)AMINE-INDUCED PANCREATIC LESIONS IN HAMSTERS

被引：15

作者：

MEIJERS, M

VANGARDERENHOETMER, A

LAMERS, CBHW

ROVATI, LC

JANSEN, JBMJ

WOUTERSEN, RA

机构：

[1] TNO,INST TOXICOL & NUTR,DEPT BIOL TOXICOL,POB 360,3700 AJ ZEIST,NETHERLANDS

[2] LEIDEN UNIV HOSP,DEPT GASTROENTEROL & HEPATOL,2333 AA LEIDEN,NETHERLANDS

[3] ROTTA RES LAB SPA,MILAN,ITALY

来源：

CANCER LETTERS | 1991年 / 59卷 / 01期

关键词：

BOMBESIN; PANCREAS; CARCINOGENESIS; HAMSTER; LORGLUMIDE;

D O I：

10.1016/0304-3835(91)90134-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bombesin (BBS) has been shown to promote pancreatic growth as well as the development of pancreatic (pre)neoplasia in rats. The present study was carried out to determine the effects of bombesin on pancreatic growth and on the development of pancreatic (pre)neoplastic lesions in hamsters treated with N-nitrosobis(2-oxopropyl)amine (BOP). Bombesin caused an increase in growth of the pancreas accompanied by a decrease in the number of (pre)neoplastic ductular pancreatic lesions. Lorglumide (CR-1409) did not influence these effects of bombesin. It is concluded that in BOP-treated hamsters the effect of bombesin on the pancreas is not mediated by cholecystokinin (CCK). These data support the existence of species difference between rats and hamsters with regard to the effect of bombesin on pancreatic carcinogenesis.

引用

页码：45 / 50

页数：6

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