ELECTROSTATIC MODELING OF DIPOLE-ION INTERACTIONS IN GRAMICIDINLIKE CHANNELS

被引：30
|
作者：
SANCHO, M
MARTINEZ, G
机构：
[1] Departamento de Física Aplicada III, Facultad de Física, Universidad Complutense, Madrid
来源：
BIOPHYSICAL JOURNAL | 1991年 / 60卷 / 01期
关键词：
D O I：
10.1016/S0006-3495(91)82032-X
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Using an electrostatic model for the pore and membrane region in a gramicidinlike channel, the effect of dipoles located inside the membrane on the ion transport are analyzed. Calculated energy profiles for different orientations of dipoles show a predominant influence of their radial components. The results qualitatively agree with experimental measurements of conductance on different modified gramicidins and allow to understand the important role of polar side chains on ion permeation.
引用
收藏
页码：81 / 88
页数：8
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