ANTIMALARIAL ARTEMISININ ANALOGS - SYNTHESIS OF 2,3-DESETHANO-12-DEOXOARTEMISININ-RELATED COMPOUNDS

被引：14

作者：

IMAKURA, Y ^{[1
]}

HACHIYA, K ^{[1
]}

IKEMOTO, T ^{[1
]}

KOBAYASHI, S ^{[1
]}

YAMASHITA, S ^{[1
]}

SAKAKIBARA, J ^{[1
]}

SMITH, FT ^{[1
]}

LEE, KH ^{[1
]}

机构：

[1] UNIV N CAROLINA,SCH PHARM,NAT PROD LAB,DIV MED CHEM & NAT PROD,CHAPEL HILL,NC 27599

来源：

HETEROCYCLES | 1990年 / 31卷 / 12期

关键词：

D O I：

10.3987/COM-90-5618

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,3-Desethano-12-deoxoartemisinin-related compounds ((+)-16a) and ((-)-16b) have been synthesized from R-(+)-citronellal (7) by a stereoselective manner, which is applied to the synthesis of various novel antimalarial artemisinin analogs.

引用

页码：2125 / 2129

页数：5

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