ANTIMALARIAL ARTEMISININ ANALOGS - SYNTHESIS OF 2,3-DESETHANO-12-DEOXOARTEMISININ-RELATED COMPOUNDS

被引：14
|
作者：
IMAKURA, Y [1 ]
HACHIYA, K [1 ]
IKEMOTO, T [1 ]
KOBAYASHI, S [1 ]
YAMASHITA, S [1 ]
SAKAKIBARA, J [1 ]
SMITH, FT [1 ]
LEE, KH [1 ]
机构：
[1] UNIV N CAROLINA,SCH PHARM,NAT PROD LAB,DIV MED CHEM & NAT PROD,CHAPEL HILL,NC 27599
来源：
HETEROCYCLES | 1990年 / 31卷 / 12期
关键词：
D O I：
10.3987/COM-90-5618
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2,3-Desethano-12-deoxoartemisinin-related compounds ((+)-16a) and ((-)-16b) have been synthesized from R-(+)-citronellal (7) by a stereoselective manner, which is applied to the synthesis of various novel antimalarial artemisinin analogs.
引用
收藏
页码：2125 / 2129
页数：5
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