STUDIES ON COGNITIVE ENHANCING AGENTS .2. ANTIAMNESTIC AND ANTIHYPOXIC ACTIVITIES OF 1-ARYL-2-(2-AMINOETHOXY)ETHANOLS

被引：0
|
作者：
ONO, S
YAMAFUJI, T
CHAKI, H
MORITA, H
TODO, Y
MAEKAWA, M
KITAMURA, K
TAI, M
NARITA, H
机构：
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1995年 / 43卷 / 09期
关键词：
1-ARYL-2-(2-AMINOETHOXY)ETHANOL; COGNITIVE ENHANCING AGENT; ANTIAMNESTIC ACTIVITY; ANTIHYPOXIC ACTIVITY; TACRINE;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 2-(2-aminoethoxy)-1-phenylethanols having a variety of N- and phenyl-substitution patterns as well as 5- and 6-memhered heteroaryl counterparts of our prototype compound 1 (2-(2-dimethylaminoethoxy)-1-phenylethanol) have been prepared and evaluated for antiamnestic and antihypoxic activities. Compound 3b, the 3-methylphenyl analogue of 1, proved to be significantly more potent than 1 in reversing electroconvulsive shock-induced amnesia as well as CO2-induced learning-impairment in mice. It exhibited low acute toxicity in mice and afforded a greater brain/serum concentration ratio than 1 after oral administration to rats.
引用
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页码：1488 / 1491
页数：4
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