PALLADIUM-CATALYZED INTRAMOLECULAR ZINC-ENE REACTIONS

被引：6
|
作者：
OPPOLZER, W
SCHRODER, F
机构：
[1] Département de Chimie Organique, Université de Genève
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 43期
关键词：
D O I：
10.1016/0040-4039(94)80016-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cyclizations of acetoxydienes 1 with Pd(PPh(3))(4)/Et(2)Zn (0.05/4-5 mol-equiv.) in Et(2)O at reflux, followed by either protonation, iodination or cyanation, provide cis-disubstituted cyclopentanes and pyrrolidines 5, 7 or 9. These tandem reactions, as well as the conversions 15 --> 17 or 18 and 20 --> 22 show good to excellent regio- and stereocontrol, which is compared to those of Pd-ene ring closures of 1 and 20.
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页码：7939 / 7942
页数：4
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