INDUCTION OF A MUCOSAL BARRIER TO BOVINE HERPESVIRUS-1 REPLICATION IN CATTLE

被引：52

作者：

ISRAEL, BA ^{[1
]}

HERBER, R ^{[1
]}

GAO, Y ^{[1
]}

LETCHWORTH, GJ ^{[1
]}

机构：

[1] UNIV WISCONSIN,DEPT VET SCI,1655 LINDEN DR,MADISON,WI 53706

来源：

VIROLOGY | 1992年 / 188卷 / 01期

关键词：

D O I：

10.1016/0042-6822(92)90755-E

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Current vaccines for human and animal herpesviruses engender an immunity that may ameliorate disease but generally fails to prevent infection, latency, reactivation from latency, or spread through a population. By administering intranasally to cattle bovine herpesvirus type 1 virion envelope proteins combined with the potent mucosal immune system adjuvant, cholera toxin B subunit, we engendered a local antibody response that acted as a barrier to infection of mucosal epithelial cells and thereby prevented viral replication, consequently precluding disease, latency, and spread. © 1992.

引用

页码：256 / 264

页数：9

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