EXTRAMACROCHAETAE, A NEGATIVE REGULATOR OF SENSORY ORGAN DEVELOPMENT IN DROSOPHILA, DEFINES A NEW CLASS OF HELIX-LOOP-HELIX PROTEINS

被引：369

作者：

ELLIS, HM ^{[1
]}

SPANN, DR ^{[1
]}

POSAKONY, JW ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,CTR MOLEC GENET,LA JOLLA,CA 92093

来源：

CELL | 1990年 / 61卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0092-8674(90)90212-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The function of the extramacrochaetae (emc) gene is required to establish the normal spatial pattern of adult sensory organs in Drosophila. emc acts to suppress sensory organ development in certain regions of the body surface, apparently by antagonizing the function of the achaete and scute genes of the achaetescute complex (AS-C). We have found that emc encodes a novel member of the helix-loop-helix (HLH) family of proteins. The emc protein shares the dimerization domain of other HLH proteins but lacks their DNA binding motif. We propose a model in which the emc protein negatively regulates sensory organ determination by forming heterodimers with the HLH proteins encoded by the AS-C and/or daughterless, thereby altering or interfering with their activity. © 1990.

引用

页码：27 / 38

页数：12

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