CLONING AND CHROMOSOME LOCALIZATION OF THE MOUSE EWS GENE

被引：5
|
作者：
PLOUGASTEL, B
MATTEI, MG
THOMAS, G
DELATTRE, O
机构：
[1] INSERM,CIF9201,GENET TUMEURS LAB,F-75231 PARIS 05,FRANCE
[2] FAC MED TIMONE,INSERM,U406,F-13385 MARSEILLE 5,FRANCE
来源：
GENOMICS | 1994年 / 23卷 / 01期
关键词：
D O I：
10.1006/geno.1994.1495
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The human EWS gene encodes a putative RNA binding protein. As a result of acquired chromosome rearrangement, the N-terminal portion of the EWS protein is fused to the DNA binding domain of either FLI-1 or ERG in the Ewing family of tumors and to the DNA binding domain of ATF1 in malignant melanoma of soft parts. We have determined the cDNA sequence of the mouse Ews gene. Its nucleotide sequence and its translation product demonstrate 93 and 98% homology with the human EWS cDNA and protein, respectively. The murine Ews locus lies within a conserved synteny segment between human chromosome 22q12 and mouse chromosome 11A1-A3. (C) 1994 Academic Press, Inc.
引用
收藏
页码：278 / 281
页数：4
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