AZICEMICIN-A AND AZICEMICIN-B, A NEW ANTIMICROBIAL AGENT PRODUCED BY AMYCOLATOPSIS .1. TAXONOMY, FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL-ACTIVITIES

被引：39

作者：

TSUCHIDA, T

IINUMA, H

KINOSHITA, N

IKEDA, T

SAWA, T

HAMADA, M

TAKEUCHI, T

机构：

[1] Institute of Microbial Chemistry, Shinagawa-ku Tokyo 141

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 03期

关键词：

D O I：

10.7164/antibiotics.48.217

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new structural class of the antibiotic, azicemicins A (1) and B (2) were isolated from the culture broth of the strain MJ126-NF4, which was closely related to Amycolatopsis sulphurea. They were purified by adsorption on Diaion HP-20, silica gel column chromatography and preparative TLC. The molecular formulas of 1 and 2 were determined to be C23H25O9N and C22H23O9N by HRFAB-MS, respectively. Azicemicins A and B have moderate growth inhibiting activity against Gram-positive bacteria and mycobacteria.

引用

页码：217 / 221

页数：5

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